Pomalidomide is used to treat multiple myeloma (cancer resulting from a progressive blood disease). Pomalidomide is usually given after at least two other medications have been tried without success.
Pomalidomide is also used to treat AIDS-related Kaposi sarcoma when other medications did not worked or have stopped working. Pomalidomide can also be used to treat Kaposi Sarcoma in adults who are HIV-negative.